Poloxamer 407 (Synperonic PE/F 127) – Nonionic Emulsifier

Poloxamer 407, marketed as Synperonic PE/F 127 by Croda, is one of the most sophisticated multifunctional ingredients available to cosmetic and pharmaceutical formulators. A nonionic block copolymer with a uniquely amphiphilic structure, it bridges the gap between oil and water with remarkable efficiency — stabilizing emulsions, solubilizing actives, and forming beautifully clear gels that feel smooth and elegant on the skin.

What sets Poloxamer 407 apart is its versatility. At low concentrations it acts as a solubilizer and emulsifier; at higher concentrations it transforms into a structured, thermoreversible gel — fluid when cold, firm at body temperature. This makes it an indispensable tool for advanced skincare, pharmaceutical, and personal care formulations.

Key Benefits

• Powerful Emulsification – stabilizes oil-in-water mixtures for long-lasting, uniform formulations
• Excellent Solubilization – effectively dissolves oils, fragrances, and actives into aqueous systems
• Clear Gel Formation – creates transparent, smooth gel textures at higher use levels
• Foam Stabilization – improves foam quality and longevity in cleansing products
• Texture & Viscosity Control – adjusts product consistency and skin feel with precision

Applications

• Creams, lotions & skincare emulsions
• Clear serums & gel formulations
• Shampoos & hair conditioners
• Body washes & facial cleansers
• Pharmaceutical gels & topical ointments
• Fragrance & essential oil solubilization

Recommended Usage Levels

Usage level varies significantly depending on the intended function — refer to your formulation type when determining the correct concentration.

Technical Profile

• INCI: Poloxamer 407
• Trade Name: Synperonic PE/F 127
• Type: Nonionic block copolymer surfactant
• Appearance: White to off-white solid / flakes
• Solubility: Water-soluble
• Function: Emulsifier, solubilizer, gel former, foam stabilizer

Formulation Tips

Add slowly to the water phase with gentle mixing to avoid excessive foaming. Ideal for clear gel systems where transparency is essential. Combine with co-emulsifiers for enhanced stability in complex emulsions. Works well in mild, skin-friendly formulations and is compatible with a wide range of cosmetic actives and preservatives.